Steroid induced brain atrophy

Benzodiazepines may influence neurosteroid metabolism by virtue of their actions on translocator protein (TSPO; "peripheral benzodiazepine receptor"). [59] The pharmacological actions of benzodiazepines at the GABA A receptor are similar to those of neurosteroids . Factors which affect the ability of individual benzodiazepines to alter neurosteroid levels may depend upon whether the individual benzodiazepine drug interacts with TSPO. Some benzodiazepines may also inhibit neurosteroidogenic enzymes reducing neurosteroid synthesis. [60]

The structure of cyclocreatine is fairly flat (planar), which aids in passive diffusion across membranes. It has been used with success in an animal study, where mice suffered from a SLC6A8 (creatine transporter at the blood brain barrier) deficiency, which is not responsive to standard creatine supplementation. [98] This study failed to report increases in creatine stores in the brain, but noted a reduction of mental retardation associated with increased cyclocreatine and phosphorylated cyclocreatine storages. [98] As demonstrated by this animal study and previous ones, cyclocreatine is bioactive after oral ingestion [98] [99] and may merely be a creatine mimetic, able to phosphorylate ADP via the creatine kinase system. [98]

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A very low carb diet is hard to maintain, and I must admit that I’ve had some bad months (and years?) since my initial success. Then it’s necessary to diet again. I also add garlic and B3 (niacin) after a particularly bad test. My current doctor (we moved out-of-state) thinks this is a rather silly idea and refuses to test for cholesterol more frequently than semi-annually. It would be encouraging to get feedback more often. It’s as if you were trying to lose weight but could weigh yourself only once a year and were not allowed to measure your waist size!

Steroid induced brain atrophy

steroid induced brain atrophy

A very low carb diet is hard to maintain, and I must admit that I’ve had some bad months (and years?) since my initial success. Then it’s necessary to diet again. I also add garlic and B3 (niacin) after a particularly bad test. My current doctor (we moved out-of-state) thinks this is a rather silly idea and refuses to test for cholesterol more frequently than semi-annually. It would be encouraging to get feedback more often. It’s as if you were trying to lose weight but could weigh yourself only once a year and were not allowed to measure your waist size!

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