Used a trial sized version, applying to specific locations for a period of two weeks and saw marked improvement to those locations even in the midst of flare ups to adjacent areas. There was minimal stinging in one of the 4 locations upon the first few applications. Now using the full-sized version to apply to additional areas. I have used a topical steroid only a handful of times and my atopic dermatitis is classified as moderate. I’ve had eczema my whole life but it only resurfaced to become troublesome in the last year. My allergist (working with my dermatoligist) said he has some patients the medication clears up completely and others it does nothing for, thus the initial spot trial. There could be additional factors involved, but for me at least, there has been a positive response to the Eucrisa and no negative (other than the co-pay insurance cost).