Neuropsychiatric: A wide range of psychiatric reactions including affective disorders (such as irritable, euphoric, depressed and labile mood, and suicidal thoughts), psychotic reactions (including mania, delusions, hallucinations, and aggravation of schizophrenia), marked euphoria leading to dependence; aggravation of epilepsy, behavioural disturbances, irritability, nervousness, anxiety, sleep disturbances, and cognitive dysfunction including confusion and amnesia have been reported. Reactions are common and may occur in both adults and children. In adults, the frequency of severe reactions has been estimated to be 5-6%. Psychological effects have been reported on withdrawal of corticosteroids; the frequency is unknown.
About half a year ago, I had bronchial asthma, and I was treated with prednisone. It helped, and I recovered, but then something else happened. I started gaining weight and gained about 10 kilograms out of the blue. I noticed when my regular clothes became too tight to wear and I had to buy new ones. Now I am on a diet and want to get back to my regular size. I go to the gym to work out and my weight is slowly going back to normal. Unfortunately, it doesn’t happen overnight. So, my advice to you is to watch your diet when you take prednisone. Try not to gain weight like I did.