The secretion of hypothalamic, pituitary, and target tissue hormones is under tight regulatory control by a series of feedback and feed- forward loops. This complexity can be demonstrated using the growth hormone (GH) regulatory system as an example. The stimulatory substance growth hormone releasing hormone (GHRH) and the inhibitory substance somatostatin (SS) both products of the hypothalamus, control pituitary GH secretion. Somatostatin is also called growth hormone-inhibiting hormone (GHIH). Under the influence of GHRH, growth hormone is released into the systemic circulation, causing the target tissue to secrete insulin-like growth factor-1, IGF-1. Growth hormone also has other more direct metabolic effects; it is both hyperglycemic and lipolytic. The principal source of systemic IGF-1 is the liver, although most other tissues secrete and contribute to systemic IGF-1. Liver IGF-1 is considered to be the principal regulator of tissue growth. In particular, the IGF-1 secreted by the liver is believed to synchronize growth throughout the body, resulting in a homeostatic balance of tissue size and mass. IGF-1 secreted by peripheral tissues is generally considered to be autocrine or paracrine in its biological action.
It’s important to understand that our EAA Complex includes all of the BCAA’s (Branched Chain Amino Acids) that you have used in the past, including a precise ratio of leucine. Research shows that blood levels of these KEY amino acids are directly related to muscle protein synthesis, so we formulated a comprehensive and efficient matrix to enhance lean mass directly and indirectly, and under various conditions. Now, that ratio is important, but there are some other very exciting points about this formula. Unlike some of the amino acid supplements on the market, you aren’t paying for cheap “filler” ingredients such as dextrose or maltodextrin when you purchase Purple Wraath. Also, we chose not to include the amino acid glutamine since it is not an essential amino acid, and our bodies can synthesize it on its own in sufficient quantities. Because the studies that we based this formula off of do not use tryptophan and since it has the potential for “sedative” like side affects, we designed Purple Wraath to be completely tryptophan-free.