Because the metabolic actions of GH are antagonistic (opposite) to those of insulin, some patients with acromegaly develop diabetes mellitus. Other problems associated with acromegaly include high blood pressure (hypertension), cardiovascular disease , and arthritis . Patients with acromegaly also have an increased risk of developing malignant tumours of the large intestine . Some somatotroph tumours also produce prolactin , which may cause abnormal lactation ( galactorrhea ). Patients with acromegaly are usually treated by surgical resection of the pituitary tumour. They can also be treated with radiation therapy or with drugs such as pegvisomant, which blocks the binding of growth hormone to its receptors, and synthetic long-acting analogues of somatostatin , which inhibit the secretion of GH.
One of the most common questions asked about Human Growth Hormone is whether it can make users grow taller. Between the ages of about 12 and 18, your body is still growing. During this time, the administration of Human Growth Hormone can help you add inches to your height. As such, Human Growth Hormone is an essential part of therapy for children who have growth disorders such as dwarfism. However, between 18 and 21 years old, growth plates on your bones fuse together and essentially “lock” your height. Administering Human Growth Hormone may cause individual bones in your body to thicken, but it will not lengthen them.
The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.