Differin Gel contains adapalene, a type of retinoid. Topical retinoids, like Differin Gel, play a crucial role in the treatment of acne. Retinoids have vitamin A activity which helps regulate cell turnover to make sure your skin goes through the right process, creating a healthier environment for skin. Regulating cell turnover helps to keep the pores from clogging and target acne before it even starts. Don’t think of Differin Gel as a spot treatment only to be used when acne rears its ugly head. In fact, if used daily, Differin Gel stops new acne from forming, resulting in improved skin tone and texture.