17 oh corticosteroids urine

Eplerenone is an antimineralocorticoid , or an antagonist of the mineralocorticoid receptor (MR). [14] Eplerenone is also known chemically as 9,11α-epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone and "was derived from spironolactone by the introduction of a 9α,11α-epoxy bridge and by substitution of the 17α-thoacetyl group of spironolactone with a carbomethoxy group". [10] The drug controls high blood pressure by blocking the binding of aldosterone to the mineralocorticoid receptor (MR) in epithelial tissues, such as the kidney. [3] Blocking the action of aldosterone decreases blood volume and lowers blood pressure. [6] It has 10- to 20-fold lower affinity for the MR relative to spironolactone , [14] and is less potent in vivo as an antimineralocorticoid. [3] However, in contrast to spironolactone, eplerenone has little affinity for the androgen , progesterone , and glucocorticoid receptors . [14] [3] It also has more consistently observed non-genomic antimineralocorticoid effects relative to spironolactone (see membrane mineralocorticoid receptor ). [3] Eplerenone differs from spironolactone in its extensive metabolism, with a short half-life and inactive metabolites. [3]

17 oh corticosteroids urine

17 oh corticosteroids urine

Media:

17 oh corticosteroids urine17 oh corticosteroids urine17 oh corticosteroids urine17 oh corticosteroids urine17 oh corticosteroids urine

http://buy-steroids.org